引用

全身青蒿素促进挤压伤后脊髓背根的再生。然而，目前尚不清楚全体性青蒿素是否也能促进周围神经再生，背根神经节(DRG)远端部分病变后的功能恢复仍不清楚。在本研究中，雄性Sprague Dawley大鼠接受了轴切开术，结扎，或压碎L5脊神经或假手术。从受伤当天开始，连续两周接受间歇性皮下青蒿素或载药治疗。损伤后监测触觉或热刺激的感觉阈值6周。在6周时间点对DRG和神经再生进行免疫组化分析。阿尔特敏可短暂逆转轴切开术、结扎或挤压伤后的触觉和热过敏。热敏感和触觉过敏在治疗结束后1周内再次出现。然而，经青蒿素治疗的神经挤压大鼠，但未行轴切开术或结扎，随后在损伤后6周，感觉阈值逐渐恢复到损伤前的基线水平。Artemin使挤压伤远端神经纤维中NF200、IB4和CGRP的标记正常化，提示神经挤压诱导的神经化学变化持续正常化。 Sciatic and intradermal administration of dextran or cholera toxin B distal to the crush injury site resulted in labeling of neuronal profiles in the L5 DRG, suggesting regeneration functional restoration of nonmyelinated and myelinated fibers across the injury site into cutaneous tissue. Artemin also diminished ATF3 and caspase 3 expression in the L5 DRG, suggesting persistent neuroprotective actions. A limited period of artemin treatment elicits disease modification by promoting sensory reinnervation of distal territories and restoring preinjury sensory thresholds.