引用

高度相互联系的体感觉和运动系统在中枢神经系统损伤后，在近或远的位置受到连通性变化的影响。单侧损伤对初级运动皮层(手区;MCI)或颈髓(C7-C8水平半切;SCI)对成年猕猴背柱核(DCN)的主要体感(皮肤)输入的影响?评价了各处理促进轴突生长的效果。在SCI组(n = 4)， 1只猴子接受对照抗体，3只猴子接受抗nogo - a抗体和脑源性神经营养因子(BDNF)联合治疗。在MCI组(n?=?4)， 2只猴子未经治疗，2只猴子接受抗nogo - a抗体治疗。采用霍乱毒素B亚单位经神经节转运注射于两侧前2指、趾，双侧比较楔形核和薄状核轴突末端野面积。C7-C8水平的单侧脊髓损伤，部分侵犯背侧小索，导致来自脚趾的纤细核输入的同侧低范围，联合治疗没有改善。无论有无联合治疗，C7-C8水平的脊髓损伤均不影响楔形核初级输入的双侧平衡。 MCI targeted to the hand area did not impact on the primary inputs to the cuneate nuclei in 2 untreated monkeys. After MCI, the administration of anti-Nogo-A antibody resulted in a slight bilateral asymmetrical extent of cutaneous inputs to the cuneate nuclei, with a larger extent ipsilesionally. Overall, remote effects following MCI or SCI have not been observed at the DCN level, except possibly after MCI and anti-Nogo-A antibody treatment.