引用

脑出血(ICH)后延迟损伤和恢复的机制仍不清楚。目前常用的脑出血模型有两种:注射胶原酶(cICH)和注射自体血(bICH)。在小鼠中，我们比较了这两种模型对初始和延迟组织损伤、运动系统连接和行为恢复的影响。不同模型间病变大小无差异。自体血液注射引起较大的质量效应和早期死亡。然而，cICH会产生更大的水肿、炎症和细胞死亡。注射胶原酶会导致更大程度的皮层连接丧失和纹状体的二次收缩。脑出血发生在纹状体的运动系统连接内。前肢运动区投影图显示，只有cICH的前肢运动皮层投影有明显的萌芽。两种脑出血模型均产生前肢运动控制缺陷。 Behavioral recovery occurs by 5 weeks in cICH and 9 weeks in bICH. In summary, cICH and bICH differ in almost every facet of initial and delayed stroke pathophysiology, with cICH producing greater initial and secondary tissue damage and greater motor system axonal sprouting than bICH. Motor recovery occurs in both models, suggesting that motor system axonal sprouting in cICH is not causally associated with recovery.