引用

手术启动促炎介质级联，导致不同程度明显的无菌炎症(SIRS)。SIRS与肠麻痹和肠屏障破坏有关，并可能导致腹腔败血症。技术进步导致了一种用于经皮耳迷走神经刺激(taVNS)的神经刺激剂的开发，该刺激剂通过激活胆碱能抗炎途径，与啮齿动物和健康受试者炎症参数的下降和蠕动的改善有关。因此，taVNS可能是预防SIRS的一种策略。neurosirs研究是一项前瞻性、随机、双臂、假对照、双盲临床试验。该研究的注册号为DRKS00016892(09.07.2020)。采用受控内毒素血症作为sirs模拟模型。在taVNS或假刺激后给予2ng /kg体重脂多糖(LPS)。与假刺激相比，主要目的是降低taVNS后SIRS的临床症状。将分析taVNS对炎症因子释放、肠道功能和重要参数的影响。TaVNS耐受性良好，几乎没有副作用。 Despite not fully mimicking postoperative inflammation, LPS challenge is the most used experimental tool to imitate SIRS and offers standardization and reproducibility. The restriction to healthy male volunteers exerts a certain bias limiting generalizability to the surgical population. Still, this pilot study aims to give first insights into taVNS as a prophylactic treatment in postoperative inflammation to pave the way for further clinical trials in patients at risk for SIRS. This would have major implications for future therapeutic approaches.